Esophageal Gland Duct Adenoma

Most adenomas of the esophagus are mucin-producing lesions in the setting of Barrett esophagus, or originate in Barrett’s metaplastic epithelium, or are composed of cells with gastric epithelial features including parietal cells. Benign ductal or glandular neoplasms not associated with Barrett esophagus are very rare. There have been several reports of esophageal adenoma developing in the submucosa without Barrett epithelium. On the basis of microscopic features, esophageal adenomas have been described as serous cystadenoma, sialadenoma papilliferum, or submucosal gland duct adenoma. However, in Korea, esophageal adnoma has never been reported. Herein, we present a typical example of esophageal adenoma with unique histologic features indicating esophageal gland duct origin.